Giachelli Lab

Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival. Chande S, Caballero D, Ho BB, Fetene J, Serna J, Pesta D, Nasiri A, Jurczak M, Chavkin NW, Hernando N, Giachelli CM, Wagner CA, Zeiss C, Shulman GI, Bergwitz C. (2020)

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PiT-2, a type III sodium-dependent phosphate transporter, protects against vascular calcification in mice with chronic kidney disease fed a high-phosphate diet. Yamada S, Leaf EM, Chia JJ, Cox TC, Speer MY, Giachelli CM. (2018)

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Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLr-/-ApoB100/100 mouse model. Scatena M, Jackson MF, Speer MY, Leaf EM, Wallingford MC, Giachelli CM. Cardiovasc Pathol. (2018)

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Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness. Durham AL, Speer MY, Scatena M, Giachelli CM, Shanahan CM. (2018)

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Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice. Yamada S, Wallingford MC, Borgeia S, Cox TC, Giachelli CM. (2018)

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Noncanonical Wnts at the Cusp of Fibrocalcific Signaling Processes in Human Calcific Aortic Valve Disease. Giachelli CM, Speer MY. (2017)

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Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice. Jackson MF, Scatena M, Giachelli CM. (2017)

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Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. Yamada S, Giachelli CM. (2017)

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Runx2 deletion in smooth muscle cells inhibits vascular osteochondrogenesis and calcification but not atherosclerotic lesion formation. Lin ME, Chen TM, Wallingford MC, Nguyen NB, Yamada S, Sawangmake C, Zhang J, Speer MY, Giachelli CM. (2016)

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Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification. Paloian NJ, Leaf EM, Giachelli CM. (2016)

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Slc20a2 deficiency results in fetal growth restriction and placental calcification associated with thickened basement membranes and novel CD13 and lamininα1 expressing cells. Wallingford MC, Gammill HS, Giachelli CM. (2016)

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SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway-Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification. Wallingford MC, Chia JJ, Leaf EM, Borgeia S, Chavkin NW, Sawangmake C, Marro K, Cox TC, Speer MY, Giachelli CM. (2017)

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Engineering macrophages to control the inflammatory response and angiogenesis. Eaton KV, Yang HL, Giachelli CM, Scatena M. (2015)

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Runx2 Expression in Smooth Muscle Cells Is Required for Arterial Medial Calcification in Mice. Lin ME, Chen T, Leaf EM, Speer MY, Giachelli CM. (2015)

Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells. Chavkin NW, Chia JJ, Crouthamel MH, Giachelli CM. (2015)

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Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. (2014)

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A current understanding of vascular calcification in CKD. Paloian NJ, Giachelli CM. (2014)

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Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm. Wallingford MC, Giachelli CM. (2014)

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Engineered biomaterials control differentiation and proliferation of human-embryonic-stem-cell-derived cardiomyocytes via timed Notch activation. Tung JC, Paige SL, Ratner BD, Murry CE, Giachelli CM. (2014)

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An inducible, ligand-independent receptor activator of NF-κB gene to control osteoclast differentiation from monocytic precursors. Rementer CW, Wu M, Buranaphatthana W, Yang HY, Scatena M, Giachelli CM. (2013)

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Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2. Crouthamel MH, Lau WL, Leaf EM, Chavkin NW, Wallingford MC, Peterson DF, Li X, Liu Y, Chin MT, Levi M, Giachelli CM. (2013)

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Vascular calcification: an update on mechanisms and challenges in treatment. Wu M, Rementer C, Giachelli CM. (2013)

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Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Scialla JJ, Lau WL, Reilly MP, Isakova T, Yang HY, Crouthamel MH, Chavkin NW, Rahman M, Wahl P, Amaral AP, Hamano T, Master SR, Nessel L, Chai B, Xie D, Kallem RR, Chen J, Lash JP, Kusek JW, Budoff MJ, Giachelli CM, Wolf M. (2013)

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Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development. Liu L, Sánchez-Bonilla M, Crouthamel M, Giachelli C, Keel S. (2013)

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Prevascularized microtemplated fibrin scaffolds for cardiac tissue engineering applications. Thomson KS, Korte FS, Giachelli CM, Ratner BD, Regnier M, Scatena M. (2013)

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Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin. Lund SA, Wilson CL, Raines EW, Tang J, Giachelli CM, Scatena M. (2013)

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Smooth muscle cell plasticity: fact or fiction? Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, Yan C, Miano JM, Owens GK. (2013)

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High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease. Lau WL, Linnes M, Chu EY, Foster BL, Bartley BA, Somerman MJ, Giachelli CM. (2012)

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RANKL enhances macrophage paracrine pro-calcific activity in high phosphate-treated smooth muscle cells: dependence on IL-6 and TNF-α. Deuell KA, Callegari A, Giachelli CM, Rosenfeld ME, Scatena M. (2012)

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Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Lau WL, Leaf EM, Hu MC, Takeno MM, Kuro-O M, Moe OW, Giachelli CM. (2012)

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Surface-bound orientated Jagged-1 enhances osteogenic differentiation of human periodontal ligament-derived mesenchymal stem cells. Osathanon T, Ritprajak P, Nowwarote N, Manokawinchoke J, Giachelli C, Pavasant P. (2013)

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Engineering biomaterials to integrate and heal: the biocompatibility paradigm shifts. Bryers JD, Giachelli CM, Ratner BD. (2012)

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Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study. Naik V, Leaf EM, Hu JH, Yang HY, Nguyen NB, Giachelli CM, Speer MY. (2012)

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Combination of Sleeping Beauty transposition and chemically induced dimerization selection for robust production of engineered cells. Kacherovsky N, Harkey MA, Blau CA, Giachelli CM, Pun SH. (2012)

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Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM. (2011)

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Direct effects of phosphate on vascular cell function. Lau WL, Pai A, Moe SM, Giachelli CM. (2011)

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Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. Pai A, Leaf EM, El-Abbadi M, Giachelli CM.  (2011)

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Matrix remodeling in vascular calcification associated with chronic kidney disease. Pai AS, Giachelli CM. (2010)

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Phosphate and vascular calcification: Emerging role of the sodium-dependent phosphate co-transporter PiT-1. Lau WL, Festing MH, Giachelli CM. (2010)

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Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Yao Y, Bennett BJ, Wang X, Rosenfeld ME, Giachelli C, Lusis AJ, Boström KI. (2010)

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Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis. Speer MY, Li X, Hiremath PG, and Giachelli CM.  (2010)

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Characterization of mandibular bone in a mouse model of chronic kidney disease. Lee MM, Chu EY, El-Abbadi MM, Foster BL, Tompkins KA, Giachelli CM, Somerman MJ. (2010)

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Vitamin D receptor activators induce an anticalcific paracrine program in macrophages: requirement of osteopontin. Li X, Speer MY, Yang H, Bergen J, Giachelli CM. (2010)

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Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries. Speer MY, Yang HY, Look A, Frutkin A, Dichek D, Giachelli CM. (2009)

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Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, Ingalls CM, Liao HW, Giachelli CM. (2009)

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Immobilization of alkaline phosphatase on microporous nanofibrous fibrin scaffolds for bone tissue engineering. Osathanon T, Giachelli CM, Somerman MJ. (2009)

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Generation of mouse conditional and null alleles of the type II sodium-dependent phosphate cotransporter PiT-1. Festing MH, Speer MY, Yang HY, Giachelli CM. (2009)

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The role of osteopontin in inflammatory processes. Lund SA, Giachelli CM, Scatena M. (2009)

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Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model. Beckstead BL, Tung JC, Liang KJ, Tavakkol Z, Usui ML, Olerud JE, Giachelli CM. (2008)

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