This lab is led by Cecilia Giachelli, the Steven R. and Connie R. Rogel Endowed Professor for Cardiovascular Innovation in Bioengineering and Assoc. Vice Provost for Research at the University of Washington. The Giachelli lab group is inventing the future of medicine by developing molecular and cellular bioengineering approaches to block ectopic calcification and promote healing, biocompatibility, tissue regeneration and biomineralization. Our research includes mechanistic studies aimed at developing novel therapeutic targets and innovative approaches for treating ectopic calcification in disease, traumatic injury, and medical devices. Another area of focus is biomolecular control of the foreign body reaction, with particular emphasis on the macrophage-mediated inflammatory response to biomaterials. We are also working to identify and apply biomimetic strategies to create biointerfaces for soft and hard tissue regeneration.