New Publication on the role of Biomechanics in Immunoengeering

Diagram illustrating interaction between therapeutic depleting monoclonal antibodies (mAb), target cells, and effector cells under vascular flow and drag force conditions. It compares normal effector cells, which break Fc-FcγR bonds under force, with glycoengineered effector cells that hold bonds under force, resulting in transiently blocked N-glycan maturation and extended mAb efficacy under flow, highlighted by labeled components and directional arrows.

Check out our new publication in Immunity on engineering force-resistant antibody-receptor interactions to enhance therapeutic antibody efficacy.

We are recruiting students at any level to expand on this finding by studying the biomechanics of interactions between antibodies and Fc-Receptors on immune cells – apply now!