The advent of effective pharmacologic compounds targeting specific signaling pathways for clinical applications has created a demand for single-cell enzymatic assays.
The lab has pioneered the development of novel microfabricated cell-array platforms to enable the analysis and isolation of cells while they remain on a culture substrate.
The ability to monitor and control the environment at the cellular and tissue level is one of the most promising applications for microengineered systems.
The research program in the Allbritton Lab is a multidisciplinary effort that brings to bear principles and techniques from chemistry, physics, engineering, and materials science to develop new assays and technologies for biomedical applications. The ongoing work in the lab comprises three major focus areas:
- Analytical techniques for single-cell biochemical assays
- Microfabricated platforms for sorting and cloning cells
- Microengineered systems for recapitulating organ level function
Many of the lab’s projects and extensive collaborations within these focus areas involve the development and application of new technologies for oncology and stem cell research.